cell-cyclecheckpointsandcancer

由 SK Panda 著作 · 2019 · 被引用 12 次 — 1–5 This review intends to introduce the basics of the cell cycle and its regulation at different checkpoints in relation to cancer. Cancer is broadly a result ...

As outlined in “Cell Cycle Checkpoints” section, cell cycle checkpoints are intended to suppress genetic instability and are often compromised in cancer cells.

由 R Visconti 著作 · 2016 · 被引用 339 次 — Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA ...

This self-destruction mechanism ensures that damaged DNA is not passed on to daughter cells and is important in preventing cancer. The spindle checkpoint.

由 M Molinari 著作 · 2000 · 被引用 464 次 — Mutations of checkpoint proteins are frequent in all types of cancer as defects in cell cycle control can lead to genetic instability. This review will focus on ...

Defective proto-oncogenes and tumor-suppressor genes act similarly at a physiologic level: they promote the inception of cancer by increasing tumor cell number ...

由 MB Kastan 著作 · 2004 · 被引用 3643 次 — Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How ...

由 B Gabrielli 著作 · 2012 · 被引用 108 次 — Loss of a checkpoint may also make cancer cells more reliant on other mechanisms to compensate for the loss of this function, and these ...